Wegovy® Tablet (Oral Semaglutide) is a prescription-only medicine approved by the MHRA in June 2026 for weight management in adults. It is the first GLP-1 receptor agonist tablet licensed in the UK for this indication. Semaglutide works by reducing appetite, increasing satiety, and supporting reduced energy intake, helping the body achieve meaningful weight loss when combined with lifestyle changes.
- First oral GLP-1 for weight loss: The first tablet form of a GLP-1 receptor agonist licensed in the UK for weight management.
- Reduces appetite and increases fullness: Helps lower daily energy intake to support sustainable weight loss.
- Once-daily dosing: A simple oral tablet taken each morning, with no injections required.
- Clinically assessed treatment: Only prescribed following a full clinical review to confirm suitability.
Wegovy tablets are intended for adults with obesity, or with overweight and at least one weight-related health condition, and should be used as part of a comprehensive, clinician-led weight management plan.
- Do not use if you:
- Are allergic to semaglutide or any of the ingredients in Wegovy tablets.
- Have a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2).
- Are pregnant, planning to become pregnant, or breastfeeding.
- Consult a doctor before use if you:
- Have a history of pancreatitis, gallbladder issues, or kidney disease.
- Are taking other medications for blood sugar control, such as insulin, as combining these with Wegovy tablets can increase the risk of hypoglycaemia (low blood sugar).
- Have gastrointestinal issues, as Wegovy tablets may cause digestive side effects.
- Discontinue use and seek medical attention if:
- You experience severe stomach pain, nausea, or vomiting (possible signs of pancreatitis).
- You notice swelling in your neck or throat or experience difficulty swallowing (potential signs of thyroid issues).
- You develop gallbladder symptoms such as pain in the upper right abdomen, fever, or jaundice.
- Not suitable for use in children: Wegovy tablets have not been studied in people under 18 years of age and are not approved for paediatric use.
Keep out of reach of children: This is a prescription medication and should only be used by individuals for whom it is prescribed.
Active Ingredient:
- Semaglutide (varied dosages starting at 3 mg): A GLP-1 receptor agonist that reduces appetite and supports weight loss by increasing feelings of fullness.
Inactive Ingredients:
- Salcaprozate sodium (SNAC), an absorption enhancer
- Microcrystalline cellulose
- Povidone
- Magnesium stearate
These ingredients help the tablet remain stable and support proper absorption of the active compound.
Common Side Effects:
- Nausea: A common reaction, especially in the early weeks of treatment.
- Diarrhoea or constipation: Digestive upset is frequently reported but may improve over time.
- Vomiting: Can occur, particularly as the body adjusts to the medication.
Less Common but Serious Side Effects:
- Pancreatitis: Symptoms include severe abdominal pain, nausea, and vomiting. Seek immediate medical attention if these occur.
- Gallbladder problems: Pain in the upper right abdomen or jaundice could indicate gallstones or other gallbladder issues.
- Low blood sugar (hypoglycaemia): Particularly if Wegovy tablets are used alongside other diabetes medications.
Rare Side Effects:
- Thyroid tumours: Report any neck swelling, difficulty swallowing, or hoarseness to your doctor.
- Kidney problems: Signs include reduced urine output and swelling in the hands and feet.
- Allergic reactions: Rash, itching, or swelling of the face or throat may indicate an allergic response.
How does Wegovy tablet work for weight loss?
Wegovy tablets contain semaglutide, a GLP-1 receptor agonist that reduces appetite, increases feelings of fullness, and helps lower daily calorie intake, supporting steady and sustainable weight loss.
Who can take Wegovy tablets?
Wegovy tablets are licensed for adults with a BMI of 30 kg/m² or above, or a BMI of 27 kg/m² or above with at least one weight-related health condition, such as high blood pressure or type 2 diabetes.
How is Wegovy tablet taken?
Wegovy tablets are taken once daily, first thing in the morning, on an empty stomach with a small amount of plain water. You should wait at least 30 minutes before eating, drinking, or taking other oral medicines.
Are there any side effects?
Common side effects include nausea, vomiting, diarrhoea, and constipation. Serious side effects, such as pancreatitis or gallbladder problems, are rare but possible.
Is Wegovy tablet available on the NHS?
Wegovy tablets are not currently routinely available on the NHS and remain under evaluation by NICE. They are presently accessible through private prescription services, subject to clinical assessment.